What do you get when you cross a day job as a Medical Histopathologist with an interest in 3D printing and programming? You get a fully-baked Open Source microscope, specifically the Portable Upgradeable Modular Affordable (or PUMA), that’s what. And this is no toy microscope. By combining a sprinkle of off-the-shelf electronics available from pretty much anywhere, a pound or two of filament, and a dash of high quality optical parts, PUMA cooks up quite possibly one of the best open source microscopy experiences we’ve ever tasted.
GitHub user [TadPath] works as a medical pathologist and clearly knows a thing or two about what makes a great instrument, so it is a genuine joy for us to see this tasty project laid out in such a complete fashion. Many a time we’ve looked into an high-profile project, only to find a pile of STL files and some hard to source special parts. But not here. This is deliberately designed to be buildable by practically anyone with access to a 3D printer and an eBay account.
The project is not currently certified for medical diagnostics use, but that is likely only a matter of money and time. The value for education and research (especially in developing nations) cannot really be overstated.
A small selection of the fixed and active aperture choices
The modularity allows a wide range of configurations from simple ambient light illumination, with a single objective, great for using out in the field without electricity, right up to a trinocular setup with TFT-based spatial light modulator enabling advanced methods such as Schlieren phase contrast (which allows visualisation of fluid flow inside a live cell, for example) and a heads-up displa ..
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