Suite of NIST Reference Materials Reflects Supply Chain and Production Stages of Ginseng Supplements

Suite of NIST Reference Materials Reflects Supply Chain and Production Stages of Ginseng Supplements



Three NIST reference materials of ginseng in different forms support ginseng supplement manufacturers’ analysis of the authenticity and purity of their products as they progress from raw material (the rhizome), to an extract of the rhizome, to the powder that becomes the finished product.


This suite of reference materials provides values for measurements of the active ingredients, ginsenosides, in ginseng supplements, and some toxic elements that can be absorbed by the ginseng plant as it grows. Manufacturers of ginseng supplements can use these reference materials to check their in-house measurements, helping to ensure that their label claims are accurate and that their products are safe and free of contaminants.


Ginseng has been used in traditional eastern medicine for millennia; It is popular around the world as an over-the-counter herbal supplement purported to reduce depression and improve stamina, concentration, and improve immunity. These reference materials are a result of a collaboration with the National Institutes of Health Office of Dietary Supplements, as are many other NIST dietary supplement reference materials. Product manufacturers and commercial test labs had requested a suite of reference materials to reflect these three different stages of ginseng preparation, because each presents different analytical challenges. In the U.S., ginseng supplements are regulated by the Food and Drug Administration under the Dietary Supplement Health and Education Act; Manufacturers and distributors are responsible for the efficacy and safety of their products and for determining if their product labels are accurate.


Ginseng Root


A unit of SRM 3384 Asian Ginseng Rhizome contains five packets of approximately 3 grams of ground rhizome.  A trained botanist identified the Asian ginseng;. The material has also been authenticated using DNA sequence analysis. NIST determined that botanical aut ..

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