Next-Generation Protein Sequencing Going Lab-to-Market

Next-Generation Protein Sequencing Going Lab-to-Market

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The Technology Maturation Accelerator Program (TMAP) was begun at NIST in 2019 to provide a platform for NIST scientists and engineers to help propel their lab-created innovations to the commercial market in an accelerated timeline. Each year, the labs at NIST submit proposals for their projects deemed the easiest to commercialize. The finalists are selected and are given a chance to pitch their innovations to a panel of venture capitalists and business experts. The judges select the winners based on the following: potential market opportunity, a unique and/or defensible component, and the ability to attract financial or venture investment to scale for their projects. Each winning team is granted a set amount of NIST funds to get their projects more market-ready in one year with the end goal of full commercialization. TMAP is a platform to help bridge the worlds of federal government and the private sector together in a collaborative effort to help drive the U.S. economy forward with the latest, cutting-edge technologies.


November of 2019 was the inaugural TMAP, which brought with it a great selection of NIST scientists and engineers and their innovations. One of the winning teams was comprised of John Marino (team leader), Zvi Kelman, and Jennifer Tullman-Arbogast of the Material Measurements Laboratory at NIST with their project entitled, “N-terminal amino acid binding (NAAB) reagents for use in next-generation protein spread prevention.” This research revolved around next-generation protein sequencing. These days, genomes tend to fall short of explaining or predicting biological systems or human health and disease. Genomes do not fully determine the complete set of proteins found in a biological system, also known as proteomes, as there are complex, regulatory processes that govern which proteins are translated from a genome and at what abundance.  Direct measurements of proteo ..

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