New Frequency Comb Can Identify Molecules in 20-Nanosecond Snapshots

New Frequency Comb Can Identify Molecules in 20-Nanosecond Snapshots

A new frequency comb setup can capture the moment-by-moment details of carbon dioxide gas escaping from a nozzle at supersonic speeds in an air-filled chamber, followed by rapid oscillations of gas due to complex aerodynamics within the chamber. The data plot shows the absorbance of light (vertical) over time (horizontal left to right) across a range of frequencies (horizontal forward to back).


Credit: G. Mathews/University of Colorado Boulder


From monitoring concentrations of greenhouse gases to detecting COVID in the breath, laser systems known as frequency combs can identify specific molecules as simple as carbon dioxide and as complex as monoclonal antibodies with unprecedented accuracy and sensitivity. Amazing as they are, however, frequency combs have been limited in how fast they can capture a high-speed process such as hypersonic propulsion or the folding of proteins into their final three-dimensional shapes.


Now, researchers at the National Institute of Standards and Technology (NIST), Toptica Photonics AG and the University of Colorado Boulder have developed a frequency comb system that can detect the presence of specific molecules in a sample every 20 nanoseconds, or billionths of a second. With this new capability, researchers can potentially use frequency combs to better understand the split-second intermediate steps in fast-moving processes ranging from the workings of hypersonic jet engines to the chemical reactions between enzymes that regulate cell growth. The research team announced its results in a pape ..

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